癌癥分泌自身抗體的作用 

1. 促進癌細胞惡變 癌癥分泌的自身抗體具有類似于生長因子的作用，直接促進癌細胞的惡變（包括增殖、遷移、侵襲和抗凋亡）。 2. 促進免疫逃逸 癌癥分泌的自身抗體，通過特定的糖基化修飾（如Ans162位點的唾液化修飾），可以從促進免疫作用轉變為免疫抑制作用。 這些唾液酸化的IgG分子可以通過與樹突狀細胞上的唾液酸受體DC-SIGN結合，抑制樹突狀細胞(DCs)和CD4+T細胞的功能。 癌癥細胞分泌抗體可以抑制ADCC功能，下調NK細胞的細胞毒活性。 

3.促腫瘤炎癥 在脂多糖(LPS)刺激后，癌癥分泌IgG顯著上調。 癌癥來源的IgG，可以通過 TLR4/TRIF/NF-kB 通路刺激腫瘤相關巨噬細胞釋放IL-1b來誘導炎癥。

Front. Immunol. 12:613530. 

癌癥分泌自身抗體 

1. 頭頸部癌 anti-SP17 anti-p53 

2. 中樞神經系統腫瘤 anti-MGMT anti-IGHG4 anti-CRYM  anti-EFCAB2  anti-STAT6  anti-HDAC7A anti-CCNB1 anti-pituitary (APA)  anti-hypothalamus (AHA) 

胃腸道腫瘤 anti-p53 anti-NY-ESO-1 anti-AEG-1 anti-CTAG2,  anti-DDX53,  anti-MAGEC1,  anti-MAGEA3, anti-GPR78 

3. 胃癌 Anti-RaIA anti-c-Myc,  anti-p16,  anti-HSPD1,  anti-PTEN,  anti-p53,  anti-NPM1,  anti-ENO1,  anti-p62,  anti-HCC1.4 anti-ALDH1B1， anti-UQCRC1， anti-CTAG1 anti-CENPF anti-14-3-3ζ 

4. 結直腸癌 anti-p53 anti-c-MYC  anti-cyclin B1  anti-p62  anti-Koc anti-IMP1 anti-survivin anti-RalA  anti-HSP70  anti-Galectin1  anti-KM-HN-1 anti-NY-ESO-1,  anti-p90,  anti-Sui1,  anti-HSP40,  anti-HCC-22-5,  anti-PrxVI,  anti-VEGF, anti-HCA25a,  anti-p62,  anti-Annexin 

5. 胰腺癌 anti-MUC4 anti-PTEN,  anti-EID 3(EP300-interacting inhibitor of differentiation 3)  anti-EH domain-containing protein 1,  anti-galactoside-binding soluble 9,  anti-BRCA1-associated protein 

6. 肝癌 anti-Sui1, anti-p62,  anti-RalA, anti-p53, anti-NY-ESO-1, anti-c-Myc anti-PTCH1、 anti-GNA11、 anti-PAX5、 anti-GNAS、 anti-MSH2、 anti-Survivin anti-HCC1、 anti-P16、 anti-P56、 anti-P90 anti-SPAG9（sperm-associated antigen 9） anti-NY-ESO-1 

7. 食管癌 Anti-TOP48 anti-P16 anti-NY-ESO-1 

8. 甲狀腺癌 Anti-Tg（thyroglobulin） 

9. 肺癌

anti-p53, 

anti-NY-ESO-1,

anti-CAGE, 

anti-GBU4-5, 

anti-Annexin 1,

anti-SOX2 , 

anti-HuD, 

anti-MAGE A4 

anti-TOP2A,

anti-ACTR3, 

anti-RPS6KA5, 

anti-PSIP1 

anti-BCL7A, 

anti-TRIM33, 

anti-MTERF4, 

anti-CTAG1A, 

anti-DDX4, 

anti-MAGEC2 

anti-MUC17, 

anti-CAMSAP2,

anti-KIF13B, 

anti-SMG1, 

anti-MED14,

anti-ALMS1, 

anti-GCC2, 

anti-TIMELESS, 

anti-TNS1,

anti-ATP1A4, 

anti-HRNR 

anti-PGP9.5, 

anti-GAGE7, 

anti-GBU4-5, 

anti-MAGE A1, 

anti-CT47A, 

anti-PAGE3, 

anti-VCX, 

anti-MAGEB1,

anti-LIN28B,

10. 乳腺癌

anti-HSP60 anti-PI3K anti-p53 anti-MNRR1 anti-HSPA4 

11. 腎上腺皮質癌 anti-FATE1 

12. 卵巢癌 anti-CA 125 anti-p53 anti-CTAG2 anti-PVR anti-TRIM39 anti-TRIM21 anti-NY-ESO-1 anti-CREB3、 anti-MRPL46、 anti-EXOSC10、 anti-BCOR、 anti-HMGN2、 anti-HIP1R、 anti-OLFM4 anti-KIAA1755， anti-CREB3 anti-PAX8 anti-CCL18  anti-CXCL1 anti-C1D,  anti-TM4SF1,  anti-TIZ,  anti-FXR1 anti-ICAM3,  anti-CTAG2,  anti-STYXL1, anti-POMC,  anti-NUDT11, anti- UHMK1,  anti-KSR1,  anti-NXF3 anti-GRP78 

13. 宮頸癌 anti-GAPDH anti-CA19-9 anti-CA15-3 anti-CEA 

14. 膀胱癌 anti-PPP1CA 

15.前列腺癌 anti-PARC anti-Fetuin-A 

16.睪丸精原細胞瘤 anti-Ta anti-Ma2 

17. 淋巴瘤 anti-Jo-1 anti-Jo-3、 anti-ssDNA、

anti-p-ANCA、

anti-ANA

anti-RF

18. 黑色素瘤 anti-ZBTB7B,  anti-PRKCH,  anti-p53TP53,  anti-PCTK1,  anti-PQBP1, anti-UBE2V1,  anti-IRF4， anti-MAPK8_tv2,  anti-MSN,  anti-TPM1 

19. 血管肉瘤 anti-p53 

20. 抗體介導的副腫瘤綜合征 Anti-phospholipid Anti- RI 

主要參考文獻

Cui M, Huang J, Zhang S, Liu Q,Liao Q and Qiu X (2021) Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis. Front. Immunol. 12:613530.

Wang, H.; Zhang, B.; Li, X.; Zhou, D.; Li, Y.; Jia, S.; Qi, S.; Xu, A.; Zhao, X.; Wang, J.; et al. Identification and Validation of Novel Serum Autoantibody Biomarkers for Early Detection of Colorectal Cancer and Advanced Adenoma. Front. Oncol. 2020, 10, 1081.

Wang, K.; Li, M.; Qin, J.; Sun, G.; Dai, L.; Wang, P.; Ye, H.; Shi, J.; Cheng, L.; Yang, Q.; et al. Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes. Cancers 2020, 12.

Perisetti, A.; Bellamkonda, M.; Konda, M.; Edwards, S.; Ali Khan, S.; Bansal, P.; Hu, Z.D.; Goyal, H. Tumor-associated antigens and their antibodies in the screening, diagnosis, and monitoring of esophageal cancers. Eur. J. Gastroenterol. Hepatol. 2020, 32, 779–788

Giovanella, L. Circulating biomarkers for the detection of tumor recurrence in the postsurgical follow-up of differentiated thyroid carcinoma. Curr. Opin. Oncol. 2020, 32, 7–12

Pei, L.; Liu, H.; Ouyang, S.; Zhao, C.; Liu, M.; Wang, T.; Wang, P.; Ye, H.; Wang, K.; Song, C.; et al. Discovering novel lung cancer associated antigens and the utilization of their autoantibodies in detection of lung cancer. Immunobiology 2020, 225, 151891

來源：閑談 Immunology 2022-03-23